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7.4 Aspirin Therapy

Supplemental Information

Patients with T2DM are at a significantly increased risk for development of heart disease (American Diabetes Association, 2014). Recent trials of aspirin use in diabetes have shown less benefit than older trials for primary prevention, perhaps due to better background A1c, blood pressure, and low-density lipoprotein control and lower smoking rates in recent trials (Rosiak, 2013; Macchia, 2012; Belch, 2008; Ogawa, 2008).

Regular use of ibuprofen may undermine aspirin's antiplatelet effects; patients taking both medications regularly should take immediate-release aspirin at least 30 minutes prior to taking ibuprofen or wait at least eight hours after ingestion of ibuprofen.