To help with side effects, can I take acetaminophen, ibuprofen, or antihistamines either before or after receiving vaccine?

Analgesics and antipyretics such as acetaminophen or ibuprofen are effective in managing post-vaccine side effects including injection-site pain, myalgias, and fever. However, the CDC does not recommend taking these medications pre-vaccine administration, because of possibility that they could blunt vaccine-induced antibody responses.

Administration of antihistamines to COVID-19 vaccine recipients prior to vaccination to prevent allergic reactions is not recommended. Antihistamines do not prevent anaphylaxis, and their use might mask cutaneous symptoms, which could lead to a delay in the diagnosis and management of anaphylaxis.

Sources

• NEJM: Vaccine FAQ
• ID Society: Vaccines FAQ
• CDC: Interim Clinical Considerations for Use of COVID-19 Vaccines Currently Approved or Authorized in the United States

Updated: February 10, 2021