To help with side effects, can I take acetaminophen, ibuprofen, or antihistamines either before or after receiving vaccine?
Analgesics and antipyretics such as acetaminophen or ibuprofen are effective in managing post-vaccine side effects including injection-site pain, myalgias, and fever. However, the CDC does not recommend taking these medications pre-vaccine administration, because of possibility that they could blunt vaccine-induced antibody responses.
Administration of antihistamines to COVID-19 vaccine recipients prior to vaccination to prevent allergic reactions is not recommended. Antihistamines do not prevent anaphylaxis, and their use might mask cutaneous symptoms, which could lead to a delay in the diagnosis and management of anaphylaxis.